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Titlebook: Chondrosarcoma; Biology and Clinical Francis J. Hornicek Book 2021 Springer Nature Switzerland AG 2021 Cartilage.Chondrosarcoma.Extraskelet

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The Future of Chondrosarcoma Research and Treatmentrs, with conventional chondrosarcomas having a notably bleak prognosis due to their resistance to available therapies. Recent technologies such as next-generation sequencing (NGS) have captured the genomic complexity of chondrosarcoma biology, including their variations in DNA mutational profiles, e
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Radiation Therapy for Chondrosarcomashould be considered for particle-based therapies (proton or carbon ion) when possible. Photon-based therapies should be delivered using advanced image guidance and intensity-modulated radiotherapy. For smaller tumors in the skull base, stereotactic radiosurgery should be considered. Radiation thera
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amines the future of chondrosarcoma management and development of novel adjuvant therapies, as well as the relationship of this disease to similar types (e.g., chordoma)... Bringing together the most up-to-date978-3-030-74571-4978-3-030-74572-1
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https://doi.org/10.1007/978-3-322-96454-0 and radiation, although rare histologies and inoperable sites will still be treated with these modalities. Notable controversies persist in the surgical treatment of low-grade chondrosarcoma, in the feasibility of limb salvage in the setting of pathologic fracture, and in the management of chondros
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Rechnungswesen, Controlling, Bankrechnenperately needed, and future clinical management will likely be informed by an improved understanding of subtype-specific pathways to aid in combination therapy selection. In this chapter, we discuss the future of chondrosarcoma research and summarize ongoing clinical trials evaluating novel approach
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