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Titlebook: Cholinergic Basis for Alzheimer Therapy; Robert Becker,Ezio Giacobini Book 1991 Springer Science+Business Media New York 1991 Alzheimer‘‘s

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Kinetics and Mechanisms of Reversible and Progressive Inhibition of AcetylcholinesteraseThis paper concerns the interaction of reversible ligands, particularly oximes, with acetylcholinesterase (AChE) and their effect upon the catalytic properties of the enzyme.
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Immunocytochemistry of Muscarinic and Nicotinic Receptors in Human BrainThis chapter is concerned with recent efforts to visualize nicotinic and muscarinic acetylcholine receptors (nAChRs, mAChRs) in the human brain on the cellular and subcellular level by means of immunocytochemistry.
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Overview: 978-1-4899-6740-4978-1-4899-6738-1
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https://doi.org/10.1007/978-3-8349-8523-1romuscular junction, in autonomic ganglia and in several areas of the brain. The activation of AChR by the acetylcholine (ACh) released from nerve terminals induces an influx of cations, mainly Na. ions, through the cell membrane, consequently depolarizing the target cell.
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Structure-Function Relationship Studies in Human Cholinesterases as an Approach for Evaluating Potenely depend on their inhibitory effects on CHEs in the treated individuals. Therefore, updated evaluation methods for these parameters should be valuable to pharmacological research focused on the development and use of cholinergic drugs.
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