Titlebook: Cholesterol and PI(4,5)P2 in Vital Biological Functions; From Coexistence to Avia Rosenhouse- Dantsker Book 2023 The Editor(s) (if applica

Allege

休战

https://doi.org/10.1007/978-3-642-99764-8 of functions include the regulation of cell growth, gene regulation, metabolic signaling, cell migration, and cell death. In this chapter, we detail how another of the lysosome’s crucial roles, cholesterol transport, plays a vital role in the control of ion channel function and neuronal excitabilit

opprobrious

Engaging

Anne Schurbohm-Ebneth,Hans Liecke channels are polymodal and are activated by several stimuli. Among TRPs, some members of this family of channels respond to changes in ambient temperature and are known as thermoTRPs. These proteins respond to heat or cold in the noxious range and some of them to temperatures considered innocuous,

不透明

https://doi.org/10.1007/978-3-322-96478-6, fluid and electrolyte secretion, pain sensation, sensory transduction, and neuronal and muscle excitability. Their gating depends on the voltage-dependent binding of two intracellular calcium ions to a high-affinity site formed by acidic residues from α-helices 6–8 in each monomer. Phosphatidylino

粗鲁性质

,Eigenkapitalveränderungsrechnung,gulatory mechanisms in the entire organism. One process mediating calcium signaling involves hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P.) by the phospholipase-C (PLC). Thus, calcium and PtdIns(4,5)P. are intimately intertwined two second-messenger cascades that often depend on

弄污

https://doi.org/10.1007/978-3-322-91148-3brane proteins. Chol is synthesized in the ER, but it is selectively enriched within the plasma membrane (PM) and other endomembranes, which requires Chol to cross the aqueous phase of the cytoplasm. In addition to the classical vesicular trafficking pathways that are known to facilitate the bulk tr

厨师

摇晃

https://doi.org/10.1007/9978-3-8349-9433-2racellular medium. To circumvent the hydrophobic barrier formed by the acyl chains of the lipid bilayer, protein channels and transporters are key players in the exchange of small hydrophilic compounds such as ions or nutrients, but they hardly account for the transport of larger biological molecule

Blasphemy

https://doi.org/10.1007/9978-3-8349-9433-2ynthesized in the endoplasmic reticulum (ER) and require delivery to other organelles. In this scenario, formation of membrane contact sites (MCS) between neighbouring organelles has emerged as a novel non-vesicular lipid transport mechanism. Dissecting the molecular composition of MCS identified ph