| 书目名称 | Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells | | 编辑 | Francisco J. Alvarez-Leefmans,John M. Russell | | 视频video | | | 图书封面 |  | | 描述 | This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at | | 出版日期 | Book 1990 | | 关键词 | attention; blood cell; cells; neurons; neuroscience; physiology; skeletal muscle | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4757-9685-8 | | isbn_softcover | 978-1-4757-9687-2 | | isbn_ebook | 978-1-4757-9685-8 | | copyright | Springer Science+Business Media New York 1990 |
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