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Titlebook: Chemotherapy in Neonates and Infants; Pharmacological Onco Carolina Witchmichen Penteado Schmidt Book 2018 Springer International Publishin

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Chemotherapy in Neonates and Infants with Cancer and Other Congenital Diseases: Down Syndrome and Hemias—with a 10- to 20-fold increased risk of developing this kind of disease—they have a markedly decreased incidence of solid tumors. These patients also have a particular profile of treatment-related toxicities [72, 73].
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Introduction,as in most references about neonates and infants, the word “neonate” refers to a baby up to 28 days after birth [3]. If a neonate is born prematurely, he can still be called by this terminology—neonate—if he was born more than 28 days previously but his postmenstrual age is ≤42–46 weeks. A baby who
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Protocols Used in Chemotherapy Treatment of Neonates and Infants,ted here are referenced in the final section of this book. Protocols may vary according to each institution. It is important to know every drug used in the protocol, to take the necessary care, and to perform the necessary examinations to avoid collateral effects and toxicity. The protocols for neon
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Drug Interactions in Neonates and Infants,hese patients. It is widely published that cow’s milk contains a high level of xanthine oxidase enzyme, which can interact with 6-mercaptopurine; this interaction is clinically significant. 6-Mercaptopurine is catabolized by xanthine oxidase to the inactive metabolite 6-thiouric acid. It is recommen
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Tumor Lysis in Neonates and Infants,erphosphatemia. Hyperphosphatemia may lead to hypocalcemia. Tumor lysis syndrome usually develops after the start of chemotherapy and may lead to acute renal failure and death, due to renal tubular precipitation of uric acid and other complications. The risk factors for development of tumor lysis sy
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Chemotherapy in Neonates and Infants with Cancer and Other Congenital Diseases: Down Syndrome and Hemias—with a 10- to 20-fold increased risk of developing this kind of disease—they have a markedly decreased incidence of solid tumors. These patients also have a particular profile of treatment-related toxicities [72, 73].
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