书目名称 | Chemotherapy and Radiotherapy of Gastrointestinal Tumors |
编辑 | Hans Otto Klein |
视频video | http://file.papertrans.cn/225/224968/224968.mp4 |
丛书名称 | Recent Results in Cancer Research |
图书封面 |  |
描述 | Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10]. Of the few drugs which are active in the advanced disease, only 5-fluorouracil (5-FU) and razoxane «±1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for long-term adjuvant treatment [2, 9]. 5-FU has been widely and intensively studied as adjuvant chemotherapy in CRC [7], but there is no unanimity that it has even the marginal influence on survival that has been claimed [3, 10]. Razoxane has not previously been tested for adjuvant or maintenance treatment in CRC. It has however a number of biological activities which might be thought useful in the treatment of residual or minimal tumours [1] and which might therefore make it useful as an adjuvant. Thus it specifically prevents tumour dissemination and metastases in some tumours and normalizes the neovasculature which the tumours induce [6, 8, 11]. The drug is not cytotoxic in the usual sense, does not affect non-dividing cells, and only blocks cell division during a brief peri |
出版日期 | Book 1981 |
关键词 | Chemotherapy; Radiotherapy; Tumor; Tumors; therapy; Radiaton Oncology |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-642-81681-9 |
isbn_softcover | 978-3-642-81683-3 |
isbn_ebook | 978-3-642-81681-9Series ISSN 0080-0015 Series E-ISSN 2197-6767 |
issn_series | 0080-0015 |
copyright | Springer-Verlag Berlin Heidelberg 1981 |