| 书目名称 | Chemokines | | 副标题 | Methods and Protocol | | 编辑 | Astrid E. Cardona,Eroboghene E. Ubogu | | 视频video | http://file.papertrans.cn/225/224913/224913.mp4 | | 概述 | Features experimental models and state of the art protocols.Delineates chemokine/chemokine receptor function and their applications in health and disease.Includes key tips and expert implementation ad | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | .Chemokines constitute a large family of structurally similar cytokines that contain a signature of conserved cysteine residues joined by disulfide bridges. Binding of chemokines to specific G protein-coupled receptors followed by downstream signaling defines their biological function. Initially, chemoattraction was the key function linked to chemokines/chemokine receptors; however, in recent years, it has become clear that chemokine ligand-receptor interactions can also modulate cellular activation, survival, and proliferation, among other functions in homeostatic and diseased states. Importantly, major advances in our understanding of chemokine biology have led to chemokine receptors becoming specific therapeutic targets with great potential. In .Chemokines: Methods and Protocols.,. .expert researchers provide practical information regarding experimental models and state of the art protocols used to delineate chemokine/chemokine receptor function and their applications in health and disease. Written in the highly successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, s | | 出版日期 | Book 2013 | | 关键词 | Chemokine function; Chemokine ligand; G protein-coupled receptors; Therapeutic targets; Proteomics | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-62703-426-5 | | isbn_softcover | 978-1-4939-6005-7 | | isbn_ebook | 978-1-62703-426-5Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media New York 2013 |
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