| 书目名称 | Chemokine Receptors in Cancer |
| 编辑 | Amy M. Fulton |
| 视频video | http://file.papertrans.cn/225/224909/224909.mp4 |
| 概述 | Cumulatively, these data indicate that chemokine receptors may serve as biomarkers of tumor behavior as well as potential therapeutic targets.It is an appropriate time to summarize what we do and do n |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells...Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a dive |
| 出版日期 | Book 2009 |
| 关键词 | angiogenesis; cytokines; metastasis; prostate cancer; tumor |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-60327-267-4 |
| isbn_softcover | 978-1-61737-885-0 |
| isbn_ebook | 978-1-60327-267-4Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Humana Press 2009 |
|Archiver|手机版|小黑屋|
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