Titlebook: Chemistry of Antibiotics and Related Drugs; Mrinal K. Bhattacharjee Textbook 2022Latest edition The Editor(s) (if applicable) and The Auth

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Development of Resistance to Antibiotics,nes, methods of transfer of resistance genes between bacteria, and the advantages of synthetic antibiotics. Contribution of subtherapeutic use of antibiotics to resistance development and the response of the governments and other regulatory agencies to address the problem are also discussed.

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Antibiotics That Inhibit Cell Wall Synthesis,discussed. The antibiotics include fosfomycin, cycloserine, β-lactams, carbapenems, bacitracin, moenomycin, mersacidin, vancomycin, and teixobactin. β-lactamase and β-lactamase inhibitors are discussed in the context of antibiotic resistance.

Connotation

Antibiotics That Inhibit Nucleic Acid Synthesis,luoroquinolones, and nitroheterocycles such as nitroimidazoles and nitrofurans, RNA synthesis inhibitors such as actinomycin D and rifamycins are also included. Mechanisms of action of these drugs and resistance development against them are discussed.

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Antibiotics That Affect the Membrane and Other Structural Targets,biotics, triclosan, isoniazid, magainin, and defensin. Inhibitors targeting the cell division protein, FtsZ is also included. Mechanisms of action of the antibiotics and resistance development against the antibiotics are discussed.

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Antifungals, Antimalarials, and Antivirals,yrimethamine, artemisinin, proguanil, amantadine, acyclovir, lamivudine, zidovudine, and HIV protease and neuraminidase inhibitors. Mechanisms of action of the drugs and resistance development against them are discussed. PCR method for the detection of point mutations is also discussed.

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Alternative Approaches for Antibiotic Discovery,um sensing, inhibition of biofilms, bacterial toxin neutralization, metal ion chelation, antibiotics from plants, nanoparticles as antibiotics, and antibiotics against persister bacteria. Methods for improved drug delivery targeting infected sites and intracellular bacteria are also discussed.

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Introduction to Antibiotics,ibiotics, discovery of the first antibiotics, penicillin, gramicidin, streptomycin, chloramphenicol, tetracycline, etc. Background biochemistry information needed for understanding mechanisms of action of antibiotics is briefly presented including discussions on enzymes, inhibitors, and thermodynami

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