Titlebook: Chemical and Biological Aspects of Steroid Conjugation; Seymour Bernstein (Senior Research Chemist and Gro Book 1970 Springer-Verlag New Y

gene-therapy

The Isolation of Steroid Conjugates,e from human urine in 1944 [5]. Nevertheless, as recently as 1953 only 4 intact steroid sulfates and 3 glucuronides had been isolated from urine and fully characterized, while none had yet been obtained from other sources such as plasma or bile. On the other hand, approximately 150 free steroids had

Irascible

Formation, Metabolism, and Transport of Estrogen Conjugates, conjugates displays significant biological activity. This is not generally true for the other steroid hormones. Finally, certain estrogen conjugates, which are barely detectable in the body fluids and tissues in the nonpregnant state, are found in thousand-fold amounts in late pregnancy, and in pro

Limpid

The Isolation and Metabolism of Conjugates of Neutral Steroids from Natural Sources,icative of glucuronic acid. Pregnanediol glucuronide was regarded as the conjugated water-soluble form in which large amounts of the steroid were excreted in the urine. This was the traditional physiologic role assigned to all steroid conjugates.

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Book 1970e. SEYMOUR BERNSTEIN Pearl River, N. Y. January, 1970 SAMUEL SOLOMON V11 CONTENTS Preface . . . . VII Nomenclature a, Discussion of Nomenclature System x b, Trivial and Systematic Names. x List of Contributors . . . . . . . . Xl Chemistry: Synthesis and Characterization S. BERNSTEIN, 1. P. DUSZA, an

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creatine-kinase

,The Biochemistry of the 3,—Hydroxy—, ,—Steroid Sulfates,in this volume a separate chapter devoted especially to this kind of steroid conjugate. However, it seems to us that there are other, more trenchant, reasons for this exceptional treatment. Although scores of steroid sulfates have been isolated or detected in body tissues and fluids, only those of t

Benzodiazepines

Formation, Metabolism, and Transport of Estrogen Conjugates,o the usual sulfate and glucuronide forms, estriol, a quantitatively important estrogen, occurs as the double conjugate, estriol-3-sulfate-16-glucuronide [1–6]. In addition, an N-acetylglucosamine conjugate of 17α-estradiol has been isolated from the urine of rabbits [7], and preliminary evidence ha

PANT

The Isolation and Metabolism of Conjugates of Neutral Steroids from Natural Sources,, and Lejwa in 1929 of a conjugated urinary steroid [1]. These investigators noted that acidification of male urine to pH 4.0–4.5 and continuous extraction with chloroform led to an enhancement of the biological activity of the extract. This observation was confirmed by Kabak in 1931 [2] and by Adle