Titlebook: Chemical Mutagens; Principles and Metho Alexander Hollaender Book 1971 Plenum Press, New York 1971 Carbamate.DNA.Mamma.amino acid.chromosom

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Physical-Chemical Methods for the Detection of the Effect of Mutagens on DNA,ver, there are imposing barriers to the study of the mutagenic effectiveness of particular compounds by determination of the physical changes they produce in DNA. The major problem comes from the amplification factor inherent in gene action. The DNA of an organism such as the bacterium ., with a tot

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Effects on DNA: Transforming Principle,hich then develops characteristics of the donor cell line. It was this experiment which led to the discovery that DNA is the carrier of heritable properties (Avery ., 1944). DNA can be purified and stored and will confer the specific properties soon after being incorporated by recipient cells. DNA f

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Mutagen Screening with Virulent Bacteriophages,have occupied the center of the molecular biologist’s arena for up to three decades. The reasons for the popularity of virus systems are as relevant now as they were in the 1930s. Viruses often excel in those properties which make microorganisms in general highly useful for genetic studies. They are

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The Detection of Chemical Mutagens with Enteric Bacteria,dicator system for mutagens. Bacteria have numerous advantages for the detection of mutagens, and we discuss these and describe various methods and strains. We also discuss the validity of the bacterial tests and their pertinence to human mutagenesis and carcinogenesis.

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Mutagenesis Studies with , Mutants with Known Amino Acid (and Base-Pair) Changes,l capacity of the mutationally altered enzyme. If the protein is inactivated by a single amino acid substitution, a limited number of specific amino acid changes will be capable of restoring catalytic activity. We expect that in some instances, because of strict functional requirements, activity, an

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Introduction: Unbound Morphogenesis in a Closed World, the underlying common thread of the book, namely the hypothesis of an emergent morphogenic society and the idea of the closure of the world. Then the theoretical approach is briefly introduced, explaining the basic meaning of social morphogenesis in the context of this work. The chapter goes on to