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Titlebook: Chemical Genomics; Reviews and Protocol Edward D. Zanders Book 2005 Humana Press 2005 Escherichia coli.Microarray.Proteomics.genetic inform

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书目名称Chemical Genomics
副标题Reviews and Protocol
编辑Edward D. Zanders
视频video
概述Includes supplementary material:
丛书名称Methods in Molecular Biology
图书封面Titlebook: Chemical Genomics; Reviews and Protocol Edward D. Zanders Book 2005 Humana Press 2005 Escherichia coli.Microarray.Proteomics.genetic inform
描述Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters.
出版日期Book 2005
关键词Escherichia coli; Microarray; Proteomics; genetic information; molecular biology; organic chemistry; prote
版次1
doihttps://doi.org/10.1007/978-1-59259-948-6
isbn_softcover978-1-61737-541-5
isbn_ebook978-1-59259-948-6Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2005
The information of publication is updating

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Computer-Aided Design of Small Molecules for Chemical Genomicsor creating molecules for chemical genomics. The design process involves manipulation of the input, modification of structural constraints, and further processing of the .-generated molecules using various modular toolkits. The development of a theoretical framework for each of these stages will pro
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Design, Synthesis, and Screening of Biomimetic Ligands for Affinity Chromatographye affinity ligands that represent a promising class of synthetic affinity ligands have been developed to target specific proteins and designed to mimic peptidal templates, natural biological recognition motifs, or complementary surface-exposed residues. These biomimetic ligands have been generated b
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The Role and Application of , Docking in Chemical Genomics Researches can be used to identify the structural features that are important for binding and for . screening efforts in which suitable binding partners can be identified. Here we describe a practical approach for setting up docking simulations using different docking programs. We also cover the analysis an
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Synthesis of Complex Carbohydrates and Glyconjugatesex5 glycoform. Genome analysis identified an open reading frame, HI1578, referred to as LgtD, whose amino acid sequence shows a significant level of similarity to those of a number of bacterial glycosyltransferases involved in lipopolysaccharide biosynthesis. To investigate its function, overexpress
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Screening for the Expression of Soluble Recombinant Protein in , in most proteomics pipelines. . (.) is the most convenient and cost-effective host, although optimal conditions for the expression of different proteins vary widely. Proteins vary in their structural stability, solubility, and toxicity in this environment, resulting in differing rates of protein de
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Production of Proteins for NMR Studies Using the Wheat Germ Cell-Free Systemerm cell-free system (without purification). A comparison of .H-.N heteronuclear single-quantum coherence (HSQC) spectra of yeast ubiquitin prepared using each method indicates that this wheat germ cell-free system may be used for rapid nuclear magnetic resonance analyses of proteins without purific
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