| 书目名称 | Chemical Carcinogenesis | | 编辑 | Trevor M. Penning | | 视频video | http://file.papertrans.cn/225/224293/224293.mp4 | | 概述 | Focuses of this volume: chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermedi | | 丛书名称 | Current Cancer Research | | 图书封面 |  | | 描述 | .This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.. | | 出版日期 | Book 2011 | | 关键词 | Cancer; Cancer Research; Carcinogenesis; Chemical | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-61737-995-6 | | isbn_softcover | 978-1-61779-729-3 | | isbn_ebook | 978-1-61737-995-6Series ISSN 2199-2584 Series E-ISSN 2199-2592 | | issn_series | 2199-2584 | | copyright | Humana Press 2011 |
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