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Titlebook: Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage; Mario Zuccarello,Joseph F. Clark,Opeolu M. Adeoye Book 2013 Spring

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Protein Biomarkers in Patients with Subarachnoid Hemorrhage, Vasospasm, and Delayed Ischemic Neurolyzed serum using pooled samples from study entry to the time of elevated TCD velocities using a protein microarray that analyzed 500 human proteins thematically oriented toward inflammation. After identifying several candidates with elevated concentrations in the pooled samples, we then used reverse
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Randomised Trial of Clazosentan, an Endothelin Receptor Antagonist, in Patients with Aneurysmal Subsubgroups, mortality/vasospasm-related morbidity was reduced in clazosentan-treated patients by 33% (8–51%) in poor WFNS (World Federation of Neurological Surgeons) grade (≥III) and 25% (5–41%) in patients with diffuse, thick SAH. Lung complications, anemia and hypotension occurred more frequently w
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Angiographic Vasospasm Versus Cerebral Infarction as Outcome Measures After Aneurysmal Subarachnoidnot correlate with an improvement on dichotomous Glasgow Outcome Scale/modified Rankin Scale (GOS/mRS). In contrast, a reduction of cerebral infarction correlated with better neurological outcomes. The heterogeneous definition of DCI in previous clinical trials did not allow pooling of the data. Con
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Systemic Interleukin-6 Levels Reflect Illness Course and Prognosis of Patients with Spontaneous Non vs. 3.0 ± 0.6 pg/ml, . = 0.001). Lc counts did not differ (11.5 ± 0.5 vs. 11.2 ± 0.6 × 10./μl, . = 0.485). Patients with non-pmSAH stayed significantly longer in the neurocritical care unit (16.4 ± 2.1 vs. 10.2 ± 1.1 days, . = 0.012). Symptomatic CVS occurred in two patients with non-pmSAH. Patient
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Beneficial Effect of Selective Intra-arterial Infusion of Fasudil Hydrochloride as a Treatment of Sscore (. = 0.016), but IAF was significantly correlated with GOS (. = 0.035). By multiple regression analysis, Hunt and Kosnik grade and CT score significantly correlated with GOS...: CT score significantly correlated with functional outcome. Although IAF, both selective and nonselective, was signif
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