Titlebook: Cerebellum as a CNS Hub; Hidehiro Mizusawa,Shinji Kakei Conference proceedings 2021 Springer Nature Switzerland AG 2021 cerebellum.evoluti

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Modeling of Human Cerebellar Development and Diseases with Pluripotent Stem Cell-Derived Brain Organed extensively using animal models, and in recent decades, molecular biological technologies have been used to uncover many cellular and molecular mechanisms of cerebellar development. However, it is still unknown whether findings in animals can be simply applied to the human cerebellum. Rapidly eme

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mGluR1 Is a Molecular “Hub” for Synapse Elimination in the Developing Cerebellumal development, a series of events termed synapse elimination. Postnatal development of climbing fiber to Purkinje cell synapses in the cerebellum is a representative model of synapse elimination. In neonatal rodents, Purkinje cells receive excitatory synaptic inputs from more than five climbing fib

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Cerebellar Lobules and Stripes, Viewed from Development, Topographic Axonal Projections, Functional cerebellar cortex, are the reflection of Purkinje cell subsets of specific molecular expression patterns. The stripes arise from rearrangement of the embryonic Purkinje cell clusters. The afferent and efferent axonal projection patterns are tightly correlated to both the lobular and striped organiz

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Olivocerebellar Somatotopy Revisitedstem. Similarly to the somatotopic representation in neocortical sensorimotor areas, the cerebellar afferent somatotopy has been discussed on from quite a while before. Recent results obtained in large-scale optical imaging of complex spikes uncovered that sensory information is represented by a lar

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Purkinje Cell Dendrites: The Time-Tested Icon in Histologyian central nervous system in vivo mainly due to the difficulty in observing and manipulating the rapid and non-synchronous changes in dendritic shapes during development. Cerebellar Purkinje cells (PCs), which slowly develop dendrites over several postnatal weeks in a relatively stereotypical manne

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Roles of Cerebellum-Brainstem Loops in Predictive Optokinetic Eye Velocity Control in Fish, Mice, anebrates, was found to be predictive. Recent studies demonstrated that the cerebellum is necessary but not sufficient for the acquisition of predictive (p) OKR. This chapter reviews recent findings on the roles of cerebellum-brainstem loops in pOKR. First, behavioral characteristics and neuronal circ

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Evolution of the Marr-Albus-Ito Modelheoretical model, and review how the original Marr-Albus-Ito model was conceived and how it has evolved. Over the past 50 years, this work has been applied to studies of behavior, granular layer encoding, memory capacity of Purkinje cells, distributed and synergistic synaptic plasticity, internal mo

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