Titlebook: Central Nervous System Metastases; Diagnosis and Treatm Rohan Ramakrishna,Rajiv S. Magge,Jonathan P.S. Kni Book 2020 Springer Nature Switze

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Basic Biology of Brain Metastasisypothesis and EMT/MET (epithelial-mesenchymal transition/mesenchymal-epithelial transition), which provide conceptual frameworks for understanding the clinical profile of CNS metastases and underlying cellular-molecular mechanisms regulating brain and CNS metastases, respectively. In addition, we wi

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Leptomeningeal Disease and the Role of Intrathecal Therapyon of the molecular phenotype of LM cancer cells is currently underway, and more work is needed to address the quantification of LM disease burden in order to better assess risk and response to treatment.

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Paraneoplastic Neurological Disordersayo Clin Proc, 85:838–854, 2010). Paraneoplastic neurological disorders (PNDs) predominately affect the nervous system and are almost all the product of an immune response to onconeural antigens of tumors that cross-react with the nervous system (Iorio R, Lennon VA, Immunol Rev, 248:104–121, 2012).

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Systemic Therapy of Brain Metastases: Lung Cancerrgeted therapies, the prognosis for patients with EGFR and ALK mutations has drastically improved, while immune checkpoint inhibitors are providing a durable response in a subset of patients. Translational research and innovative clinical trials will continue to produce new therapeutic options, hope

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