Titlebook: Central Nervous System Metastases; Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffi Book 2020 Springer Nature Switzerland AG 2020 Brain

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Roland Weistroffer,Subhash Narulavent of targeted therapies. BM management has dramatically evolved over the last 15 years and uses varying strategies including more or less aggressive local treatments, sometimes combined with systemic therapies that led to an improvement of patient’s survival and quality of life. Surgical resectio

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Epidemiology of Central Nervous System Metastases. Although brain metastases are the most common brain tumors, the exact incidence or prevalence is unavailable, and estimates vary considerably. Cancers most likely to metastasize to the brain are lung, breast, melanoma, renal, and colorectal cancers. The incidence of brain metastases varies widely

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Molecular Mechanisms in Brain Metastasisof other aspects of carcinogenesis. Of all sites of metastases, those to the central nervous system (CNS) result in disproportionate disability and death [2, 3], reflecting both the physiologic primacy of the CNS and our insufficient understanding of this site of metastasis. Metastasis is perhaps th

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Genomic Characterization of Brain Metastases: Implications for Precision Medicineadult cancer patients [1]. Improved systemic therapies and the advancement of neuroimaging techniques have largely contributed to a longer survival of affected patients, an earlier detection of brain metastases, and therefore a rising incidence of brain metastases [1, 2]. Among all cancer types, lun

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Preclinical Models of Brain Metastasesthe movement to and progressive colonization of distant sites by tumor cells, comprises convoluted and dynamic stages: (1) the tumor cells migrate away from the primary tumor; (2) acquire the capacity to intravasate and survive in the vasculature; (3) extravasate at a distant organ to finally surviv

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