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Titlebook: Central Nervous System Diseases and Inflammation; Thomas E. Lane,Monica Carson,Tony Wyss-Coray Book 2008 Springer-Verlag US 2008 Antigen.C

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MHC Class I Expression and CD8 T Cell Function: Towards the Cell Biology of T-APC Interactions in tg the activation as well as the effector phase. The central nervous system (CNS) is unique in that cells resident in the parenchyma, glia and neurons, do not constitutively (or very sparsely at best) express MHC molecules (Aloisi et al., 2000; Sedgwick and Hickey, 1997; Xiao and Link, 1998), making
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Organtransplantation in Rats and Miceacellular senile plaques composed primarily of beta amyloid (Aβ) peptides and intracellular inclusions, termed neurofibrillary tangles, made up of primarily hyperphosphorylated tau protein (Braak and Braak, 1997a, b; Grundke-Iqbal et al., 1986; Selkoe, 2001). In addition, AD brains demonstrate signi
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https://doi.org/10.1007/978-3-642-72140-3er and outer vascular basement membrane of arterioles, capillaries, and venules, and are thus part of the vascular wall. In standard hematoxylin-eosin or Nissl-stained sections, pericytes are difficult to recognize, but they can be identified under the electron microscope and in semithin sections, w
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Organinsuffizienz und Multiorganversagen the immune systems. Recent studies have revolutionized our understanding on how glial cells, T cells and neurons interact with each other and respond to damage in the nervous system. This chapter aims to summarize the advances of in vivo imaging as they relate to microglial activation and present t
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Kasuistik: Multiorganversagen nach Trauma,ease. Chief among those factors are cytokines, which were originally described to regulate communication between immune cells. The purpose of this chapter is to review what is known regarding normal expression of key cytokines and their receptors in the CNS as well as their roles in development and
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Organinsuffizienz und Multiorganversagenincluding neurotransmitters, growth factors, and cytokines (Farooqui et al., 2006). As illustrated in Fig. 6.1, three enzyme systems act on AA to generate prostaglandin H. via the cyclooxygenase enzymes (COX-1 and COX-2), leukotrienes via the LOX pathways, and epoxyeicosatrienoic acids via the epoxy
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Organinsuffizienz und Multiorganversagen inflammation and/or repair of the host. While the adaptive immune responses that include specific antibody and T cells are critical in eliminating many pathogenic organisms, the first immune responses are provided by the innate immune system. This immediate response is critical in assessing the lev
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