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Titlebook: Central D1 Dopamine Receptors; Menek Goldstein,Kjell Fuxe,Irving Tabachnick Book 1988 The Editor(s) (if applicable) and The Author(s), und

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书目名称Central D1 Dopamine Receptors
编辑Menek Goldstein,Kjell Fuxe,Irving Tabachnick
视频videohttp://file.papertrans.cn/224/223175/223175.mp4
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Central D1 Dopamine Receptors;  Menek Goldstein,Kjell Fuxe,Irving Tabachnick Book 1988 The Editor(s) (if applicable) and The Author(s), und
描述The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2
出版日期Book 1988
关键词biochemistry; interaction; interdependence; media; physiology; proteins; regulation
版次1
doihttps://doi.org/10.1007/978-1-4899-2723-1
isbn_softcover978-1-4899-2725-5
isbn_ebook978-1-4899-2723-1Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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0065-2598 ing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 978-1-4899-2725-5978-1-4899-2723-1Series ISSN 0065-2598 Series E-ISSN 2214-8019
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Der Netzwerkansatz in der Praxis,e basal ganglia and substantia nigra, dopamine is one of the first messengers that regulate synapsin I phosphorylation (Walaas and Greengard, unpublished observations). Synapsin I is associated with small (50 nm) synaptic vesicles (DeCamilli et al., 1983a), is present in all nerve terminals (DeCamil
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https://doi.org/10.1007/978-3-642-60270-2. An affinity chromatography purification procedure has been developed for the D. dopamine receptor. This procedure affords a substantial purification (>1000 fold) of the receptor solubilized from bovine anterior pituitary glands with complete retention of its binding properties. These biochemical t
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Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia,e basal ganglia and substantia nigra, dopamine is one of the first messengers that regulate synapsin I phosphorylation (Walaas and Greengard, unpublished observations). Synapsin I is associated with small (50 nm) synaptic vesicles (DeCamilli et al., 1983a), is present in all nerve terminals (DeCamil
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