Titlebook: Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres; John M. G. Davis,Marie-Claude Jaurand Conference proceedings 199

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https://doi.org/10.1007/978-3-642-05404-4roperoxide. The quenchers of reactive oxygen species (ROS) afforded protection against these DNA damage. These results suggest that asbestos in the presence of H.O./organic peroxides damages DNA which is mediated by the generation of oxygen free radicals. The implications have been made for the sign

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Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres

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Fiber-Induced Hydroxyl Radical Formation and DNA Damagethan at pH 4.0. These results suggest that the ability of fibers to induce varying amounts of injury to different cell types may be due to differing pH effects within cellular regions. The capacity of crocidolite to induce DNA damage was determined by measuring p53 expression. Crocidolite induced ex

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The Role of Iron in Asbestos-Induced Cancerasbestos fibers [Hobson .. (1990)]. Desferrioxamine B, an iron-specific chelator, reduced the cytotoxicity of asbestos to a variety of different cultured cell types, suggesting that iron may be involved in the cytotoxicity of asbestos [Goodlick and Kane (1986); Shatos .. (1987); Garcia .. (1988); Ka

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Transcriptional Regulation of IL-1ß and IL-6 by TNF-α in Asbestosis is Mediated by NF-IL6-like Motify stimulated a -130/+15 IL-1ß genomic fragment and a -158/-49 IL-6 fragment using the CAT assay. We found two NF-IL6 motifs in these fragments that mediated transcription in an independent manner. Interestingly, the IL-6 gene had a NF-κB motif downstream of the NF-IL6 sites that appeared to be even

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Augmentation in the Differential Oxidative DNA-Damage by Asbestos in Presence of H2O2 and Organic Peroperoxide. The quenchers of reactive oxygen species (ROS) afforded protection against these DNA damage. These results suggest that asbestos in the presence of H.O./organic peroxides damages DNA which is mediated by the generation of oxygen free radicals. The implications have been made for the sign

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