Titlebook: Cellular and Molecular Control of Neuronal Migration; Laurent Nguyen,Simon Hippenmeyer Book 2014 The Editor(s) (if applicable) and The Aut

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The Chemistry of Enols and Enamines,erin expression. As the same transcription factors have been shown to control motor axon innervation of target muscles, a simple mechanism of topographic organisation specification is becoming evident raising the question of how coordinating soma position with axon trajectory might be important for nervous system wiring and its function.

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Book 2014al migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways

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The Chemistry of Enols and Enamines,though a cohort of signaling pathways has been implicated in the regulation of cortical projection neuron migration, the precise molecular mechanisms and how a balanced interplay of cell-autonomous and non-autonomous functions of candidate signaling molecules controls the discrete steps in the migra

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The Chemistry of Enols and Enamines,on. The consequences of failure or delay in neuronal migration cause a wide range of disorders, such as lissencephaly, schizophrenia, autism and mental retardation. Neuronal migration is a dynamic process, which requires dynamic remodeling of the cytoskeleton. In this context microtubules and microt

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https://doi.org/10.1007/978-3-642-03651-4namic microtubule cytoskeleton. Microtubules are required for interkinetic nuclear migration, the separation of chromatids in mitosis, nuclear translocation during migration and the outgrowth of neurites. Their importance is underlined by the finding that mutations in a host of microtubule associate

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The Chemistry of Enols and Enamines,ropriate connections with their target cells. These events require coordinated activity of multiple elements of the cytoskeleton, in which the MARK/Par-1 polarity kinase plays an important role. Here, the various roles and modes of regulation of MARK/Par-1 are reviewed. MARK/Par-1 participates in ax

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The Chemistry of Enols and Enamines, example of such order is the myotopic organisation of the motor system where spinal motor neuron position parallels that of target muscles. This chapter will discuss the molecular mechanisms underlying motor neuron soma positioning, which include transcriptional control of Reelin signaling and cadh