| 书目名称 | Cellular Rhythms and Networks | | 副标题 | Implications for Sys | | 编辑 | Qing Yan | | 视频video | http://file.papertrans.cn/224/223066/223066.mp4 | | 概述 | Provides a thorough, systematic overview of cellular rhythms and their roles in complex diseases and the development of medicines.Explains and defines the circadian clock which is critical to understa | | 丛书名称 | SpringerBriefs in Cell Biology | | 图书封面 |  | | 描述 | This book provides an overview of circadian rhythms and cellular networks in their relation to biological systems and dynamical medicine. Six concise chapters explore circadian cell rhythms and biomarkers in inflammation, cardiovascular disease, cancer, depression, and more in causing and treating these ailments. The final chapter discusses optimization of drug delivery and individualized treatment systems using chronotherapy and chronobiology-based biomarkers as a general system of medicine. Succinct yet comprehensive, Cellular Rhythms and Networks, part of SpringerBriefs in Cell Biology presents a novel framework for clinical applications in personalized and systems medicine. It is invaluable reading for researchers and clinicians in cell biology, mood disorders, and systems medicine. | | 出版日期 | Book 2015 | | 关键词 | biomarkers; chronotherapy; circadian rhythm; mood disorders; systems medicine; Cell Cycle Analysis; System | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-22819-8 | | isbn_softcover | 978-3-319-22818-1 | | isbn_ebook | 978-3-319-22819-8Series ISSN 2625-3534 Series E-ISSN 2625-3542 | | issn_series | 2625-3534 | | copyright | Springer International Publishing Switzerland 2015 |
| 1 |
Front Matter |
|
|
Abstract
|
| 2 |
,Introduction: Cellular Rhythms and Networks in Systems and Dynamical Medicine, |
Qing Yan |
|
Abstract
Temporal elements such as rhythms are essential properties of biological organisms. Rhythmic physiological and psychological activities are maintained on the basis of complex interactions among components at various spatiotemporal levels from molecules to cells and organisms, from seconds to days and years. A systems biology perspective is necessary to understand the dynamical patterns and to characterize their functions, targets, and interactions. Studies of the biological rhythms at different levels such as the cellular level may have profound implications for health care. The development of systems and dynamical medicine would address the timely changes in the whole system. Such approaches would enable the establishment of systemic models for psychophysiological and pathological oscillations and feedback loops. The identification of the clusters of robust biomarkers such as cellular rhythmic networks may help improve the accuracy in the risk identification and prediction of disease progression. The development in systems biology based on both experimental and computational technologies would allow for the translation of the spatiotemporal models into the clinical practice of per
|
| 3 |
,Circadian Rhythms and Cellular Networks: A Systems Biology Perspective, |
Qing Yan |
|
Abstract
The multi-scale view of circadian rhythms on the basis of systems biology would empower the discovery of novel therapeutic strategies such as chronotherapy. Depending on the feedback loops with multiple pathways and complex protein–protein interactions involved, the circadian clocks form the basic cellular timing mechanisms that synchronize vital physiological processes. The two essential cellular rhythms, the cell division cycle and the circadian pattern are coupled oscillators with intertwined bidirectional circuits. The circadian regulation of cell cycle may provide the molecular and cellular linkages among aging, cancer, and chronotherapy with implications for better drug efficacy and tolerance. Approaches including gene expression profiling and proteomic analyses are re-shaping our understanding of the circadian systems. Systems biology methods such as genetic perturbations and computational modeling within each scale may contribute to the advancement of systems and dynamical medicine.
|
| 4 |
,The Circadian–Immune Crosstalk and Inflammation: Implications for Disease Treatment, |
Qing Yan |
|
Abstract
Chronic inflammation is an important risk factor for many diseases including cardiovascular disease and cancer. The disturbance of circadian rhythms may lead to various pathophysiological and clinical states from inflammation to type 2 diabetes. The interconnections between the immune system and the circadian oscillating systems are bidirectional at multiple levels. While the clock proteins may control cytokine expressions, proinflammatory cytokines may convey feedback to the molecular clocks and cell cycles. At the system level, the HPA axis has a critical role. Complex pathways and feedback loops are involved in the circadian–neuroendocrine–immune interrelationships. A systemic understanding incorporating psychological and environmental interactions is necessary to achieve the integrative view of inflammation. The multi-factorial interactions among circadian disruptions, inflammation, metabolism processes, and epigenetic activities may be involved in diseases including the lung, heart, and gastrointestinal disorders, as well as aging and arthritis. Such understanding on the basis of systems biology may have profound implications for better therapeutic strategies such as using chr
|
| 5 |
,Circadian Rhythms and Cellular Networks in Depression and Associated Disorders, |
Qing Yan |
|
Abstract
Increasing evidences have indicated that circadian disruptions may be an essential factor in the pathophysiology of anxiety, major depressive disorder (MDD), bipolar disorders, and seasonal affective disorder (SAD). Depression and abnormal circadian rhythms may share a common etiology with lower cellular resilience and resistance to stressful events. On the basis of systems biology, factors at various levels have been associated with the development of depression, including alterations in the circadian pathways, HPA-axis, and human–environment interactions. Variants in the circadian genes have significant roles in the susceptibility and recurrence of mood disorders. The pattern analysis of systemic circadian profiles can be useful for the prediction and prevention of various psychiatric disorders with implications for personalized diagnosis and treatment. Chronotherapy such as scheduled medications indicate that the circadian systems may be a crucial target for the better treatment of depression and associated disorders.
|
| 6 |
,Circadian Rhythms and Cellular Networks in Cardiovascular Diseases, |
Qing Yan |
|
Abstract
The elucidation of cellular processes and rhythms are critical for understanding the mechanisms of cardiovascular diseases. The cardiovascular system responds to environmental stimuli in circadian patterns. Such patterns are mediated via complex interactions between the extracellular factors such as neuro-humoral elements and intracellular factors such as the clock genes. The expression cycles of metabolic genes in cardiovascular tissues may interact with the transcriptional regulation of the circadian genes in a bidirectional manner. Together with the circadian rhythms, cell cycle also has an essential role in cardiovascular functions. Clock genes are regulated by the circadian oscillations not just in the SCN central clock but also in various peripheral tissue cells. The maintenance of the normal circadian time structure is critical for preventing cardiovascular diseases and associated disorders including aging and chronic kidney disease. For a systemic understanding of the circadian–cardiovascular interactions, life style is also important. The connections among shift work, metabolic risks, and cardiovascular diseases have been well established. The circadian rhythms may have a
|
| 7 |
,Circadian Rhythms and Cellular Networks in Cancer, |
Qing Yan |
|
Abstract
As an important risk factor, the disruption of the clock functions may contribute to the development and progression of cancer. Molecular, cellular, and clinical studies have identified biological and behavioral factors associated with circadian patterns as potential biomarkers. Alterations in the clock genes such as mutations and epigenetic silencing have been related to higher risks for cancer. At the cellular level, circadian disruptions in various cell types and peripheral tissues may affect the cellular functions including cell metabolism, DNA repair, aging, and extracellular signaling. Because the circadian systems are tightly linked to cell proliferation and apoptosis, altered circadian–cell cycle interactions have critical roles in carcinogenesis. Connections have been established between the alterations in the circadian pathways and various cancer types including skin cancer. Life style changes such as shift work may also be associated with cancer development via systemic factors including melatonin suppression, immune dysfunctions, and metabolic alterations. The understanding of such complex interrelationships on the basis of systems biology may contribute to the optimiza
|
| 8 |
,Circadian Biomarkers and Chronotherapy: Implications for Personalized and Systems Medicine, |
Qing Yan |
|
Abstract
The advancement in chronotherapy may enrich the practice of personalized and systems medicine. Biomarkers based on chronobiology and systems biology can be used for the establishment of systemic rhythmic profiles toward more precise diagnosis and individualized treatment. Strategies in chronotherapy can be applied for the optimized timing, amount, and composition of drug administration to promote the efficacy and minimize the toxicity. Novel drugs can also be designed to target the relevant circadian mechanisms and chrono-biomarkers associated with pathogenesis such as inflammation. Preliminary screening of novel therapeutics for their potentials in chronotherapy may become an innovative strategy for promoting the quality of medical practice. With multi-directional connections across various levels, systemic factors including cellular networks, rhythmic behaviors, and lifestyle can be integrated into the comprehensive therapeutic profiles. The applications of personalized chronotherapy may provide benefits for the treatment of various diseases including cancer, depression, hypertension, and rheumatoid arthritis.
|
| 9 |
Back Matter |
|
|
Abstract
|
|
|
|Archiver|手机版|小黑屋|
派博传思国际
( 京公网安备110108008328)
GMT+8, 2025-7-20 12:26
发表于 2025-3-21 16:19:14
