Titlebook: Cellular Bioenergetics: Role of Coupled Creatine Kinases; Valdur A. Saks,Renée Ventura-Clapier Book 1994 Springer Science+Business Media D

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A brief summary of the history of the detection of creatine kinase isoenzymeszymes, isoforms of enzymes, etc.’. Markert and Moller [1] introduced for the first time these terms for multiple molecular forms of a given enzyme existing in a single organism or tissue and having identical or at least nearly identical catalytic activities. At the time, it was an operational defini

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Metabolic regulation of , myocardial contractile function: multiparameter analysist animal models were instrumented for routine physiological measurements of mechanical function and for measurements of metabolism (.P NMR, NADH fluorescence (redox state)) and perfusion (.H NMR and Laser doppler techniques). These techniques were applied to canine and cat models of volume and/or pr

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Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and ply be regarded as an energy buffer. Thus an understanding of its role in smooth muscle behavior can point to CK function in other systems. From our perspective CK function in smooth muscle is one example of a more general phenomenon, that of the co-localization of ATP synthesis and utilization. In

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The importance of the outer mitochondrial compartment in regulation of energy metabolismge in regulation of oxidative phosphorylation. The differences compared to conventionally isolated mitochondria were that stimulation of oxidative phosphorylation appeared to rather depend on the activity of peripheral kinases than on the addition of free ADR The localisation of peripheral kinases s

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The influence of the cytosolic oncotic pressure on the permeability of the mitochondrial outer membron of isolated mitochondria. Under these conditions the volume of the intermembrane space decreases and the contact sites between the both mitochondrial membranes increase drastically. These morphological changes are accompanied by a reduced permeability of the mitochondrial outer compartment for ad

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Myofibrillar creatine kinase and cardiac contractioneatine kinase as an integral structural part of the complex organization of myofibrils in striated muscle. The second part considers the intrinsic biochemical and mechanical properties of myofibrils and the functional coupling between myofibrillar CK and myosin ATPase. Skinned fiber studies have bee