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Titlebook: Cell to Cell Signals in Mammalian Development; S. W. Laat,J. G. Bluemink,C. L. Mummery Conference proceedings 1989 Springer-Verlag Berlin

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Mutational Analysis of the EGF Receptor Proto-Oncogenending of basic biological problems in the areas of cell biology, endocrinology and development. As a first step toward the detailed analysis of growth factor activated cellular signalling mechanism, structural characterization of the RTK family resulted in complete primary structures of all known RT
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The Macrophage Colony Stimulating Factor, CSF-1, and Its Receptor (c-,)vely. Recently, each of these CSFs has been purified to homogeneity, and cDNA clones encoding the factors have been exploited to produce previously unrealizable quantities of CSFs for experimental and therapeutic use. CSFs are already proving their efficacy in clinical trials and have numerous poten
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Regulation of Growth Factors and their Receptors in Early Murine Embryogenesisaeras when injected into normal blastocysts. Embryonic stem (ES) cells established in vitro directly from isolated ICM’s (Martin 1981; Evans and Kaufman 1981) readily form normal chimaeras and as such are much closer to their embryonic origins. Further, EC cell lines require chemical induction of di
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The Murine Homeobox Protein Hox 1.1 Is Differentially Expressed in Embryonal Mesoderm and Ectodermsequences homologous to developmental control genes of Drosophila could lead to the identification of genes with a related function in the mammalian genome. Indeed, based on this hypothesis, several candidates for mammalian developmental control genes have been identified. Undoubtedly most effort ha
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Regulation of Expression of the Hox 2.3 Genete embryology concentrate their attention on genes for which the evidence implicating them in pattern formation is only circumstantial. The homeobox containing genes (1), found throughout the animal kingdom including mice and humans, exemplify such genes. In the genetically well-characterized fruitf
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Analysis of transcription of the murine homeobox gene Hox 1.3Niisslein-Volhard et al.), define the segmentation (rev. Scott and Carroll), determine individual segmental characteristics (rev. Gehring), and establish neuronal identities (Doe et al.). These genes were discovered by the effects of mutations which disturbed embryogenesis. Many of the genes which t
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