| 书目名称 | Cell Stress Proteins | | 编辑 | Stuart K. Calderwood | | 视频video | | | 概述 | Provides overview of the diversity and complex evolutionary history of cell stress proteins | | 丛书名称 | Protein Reviews | | 图书封面 |  | | 描述 | Stressproteinssuchastheheatshockproteins(Hsp)andglucose-regulatedproteins (Grp) are front-line molecules in responses to cellular insult and play key roles in the viability of single cell organisms exposed to environmental stresses. However, the discovery of the roles of Hsp and Grp as molecular chaperones indicates much wider functions in the physiology of cells and organisms. It is now clear that some stress proteins are expressed constitutively and are key mediators of housekeeping protein folding in the day-to-day existence of the cell. The maturation of enzymes, transcriptionfactors,andcellsurfacereceptorsreliesonthesefunctionsofthestress proteins. In addition, the ability of stress proteins to manipulate the structures of target proteins has lent them cell regulatory properties over and above their role in folding the proteome and they play key roles in controlling signal transduction, cell death pathways and transcription. Recently, novel extracellular roles for the Hsp have also emerged as it has become apparent that the Hsp can escape from the cytoplasm of cells and play a signi?cant extracellular role in signaling to neighbor cells and in immunosurveiIlance. As might be e | | 出版日期 | Book 2007 | | 关键词 | Antigen; Cell Stress; Chaperone; Immunity; Nucleotide; Proteins; Regulation; biochemistry; cell biology; mole | | 版次 | 1 | | doi | https://doi.org/10.1007/978-0-387-39717-7 | | isbn_softcover | 978-1-4419-2291-5 | | isbn_ebook | 978-0-387-39717-7 | | copyright | Springer-Verlag New York 2007 |
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发表于 2025-3-21 20:03:14
