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Titlebook: Cell Regulation by Intracellular Signals; Stéphane Swillens,Jacques E. Dumont Book 1982 Springer Science+Business Media New York 1982 calc

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12.1.1.2.1.4 Anion radicals from biacyls,urotransmitters and many hormones serve as intercellular signal molecules that alter target cell function upon interaction with cell surface, structure-specific receptors. Beta adrenergic receptors (BAR) can be included in this class of plasma membrane proteins that mediate transmembrane processes.
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12.1.1.2.1.4 Anion radicals from biacyls, active state, isolate and identify its components and reassemble the whole in a functional form. The first step of this process requires the use of detergents to solubilize adenylate cyclase since the enzyme is firmly membrane bound in all eukaryotic cells, except those from the mature rat testis..
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12.1.1.2.1.4 Anion radicals from biacyls,etation of these results usually leads to a general scheme describing the relations between the different components of the system. Such a scheme is, more often than not, a set of descriptive sentences, which are sometimes illustrated by a picture where arrows and conventional signs define biochemic
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12.1.1.2.1.4 Anion radicals from biacyls,m GTP, was first described in 1969.. Because of its chemical similarity to cyclic AMP, cyclic GMP has long been assumed to be involved in cellular regulation. This assumption has been reinforced by observations that cellular levels of cyclic GMP rapidly increase in response to agonists that affect s
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12.1.1.2.1.4 Anion radicals from biacyls,fects are mediated by membrane-bound receptors and generally involve intracellular signals or “second messengers”. One part of these fast cellular hormone responses is triggered by an increased formation of cyclic AMP. The effects of β-adrenergic agonists, of histamine via H.-receptors, some effects
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12.1.1.2.1.4 Anion radicals from biacyls,ters, antigens and mitogens and cell-bound receptors play a major role. Complex networks of interacting ligands and cells have been described in areas as diverse as endocrinology, immunology and neurobiology. Few receptor-ligands systems have however been studied at the molecular level and even fewe
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12.1.1.2.1.4 Anion radicals from biacyls, This is partly because of the way in which cyclic AMP was discovered: this discovery was in fact the logical outcome of a beautiful series of experiments by Sutherland, Rall and their co-workers, designed to show that a hormone (epinephrine) could work in cell-free systems. That hormones could do s
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12.1.1.2.1.4 Anion radicals from biacyls,49 lymphoma cells. S49 clones having alterations in the pathway of cyclic AMP generation and function have proved useful in characterizing components involved in hormonal stimulation of adenylate cyclase, in activation of cAMP-dependent protein kinase, and in studying more distal cellular events med
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