| 书目名称 | Cell Line Development |
| 编辑 | Mohamed Al-Rubeai |
| 视频video | http://file.papertrans.cn/223/222836/222836.mp4 |
| 概述 | Presents an overall picture of the current state of knowledge in Cell Line Development.Designed to offer a state-of-the-art review with in–depth assessments and perspectives of expression engineering |
| 丛书名称 | Cell Engineering |
| 图书封面 |  |
| 描述 | .Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms...This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of e |
| 出版日期 | Book 2009 |
| 关键词 | Activation; CMV; Expression; RNA; biotechnology; gene expression; methodology; protein; proteins; transgen; tr |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-90-481-2245-5 |
| isbn_softcover | 978-94-007-3040-3 |
| isbn_ebook | 978-90-481-2245-5Series ISSN 1389-6946 Series E-ISSN 2542-9515 |
| issn_series | 1389-6946 |
| copyright | Springer Science+Business Media B.V. 2009 |
|Archiver|手机版|小黑屋|
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