Titlebook: Cell Culture Engineering and Technology; In appreciation to P Ralf Pörtner Book 2021 The Editor(s) (if applicable) and The Author(s), under

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Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Cultures the fastest-growing segment of the global biopharmaceutical market. During process development, scale-up is done stepwise from micro-bioreactors or shake flasks, to benchtop bioreactors, passing by pilot-scale platforms before finally being implemented in industrial-scale vessels. However, achievin

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Intensified and Continuous mAb Production with Single-Use Systemsic and autoimmune diseases. Their commercial production processes are mainly based on Chinese hamster ovary (CHO) suspension cells, which are currently cultivated in fed-batch mode at cubic meter scale. The annually growing market for therapeutic mAbs and the pressure on producers to reduce their ma

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Mathematical Modelling of Cell Culture Processesdels can be used to simulate mammalian cells. Modelling of bioprocesses largely benefit from including kinetics, which reflects the influence of metabolites or other factors on the process variables. Due to the complexity of the kinetic models, with the challenges of determining the kinetic equation

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Filtering of spatio-temporal fields, these challenges. This chapter describes the current and future cell engineering strategies to achieve high therapeutic protein productivity with desired product quality in biotechnologically important mammalian cell lines.

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Next-Generation Cell Engineering Platform for Improving Recombinant Protein Production in Mammalian these challenges. This chapter describes the current and future cell engineering strategies to achieve high therapeutic protein productivity with desired product quality in biotechnologically important mammalian cell lines.

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