Titlebook: Cell Adhesion Molecules; Cellular Recognition Martin E. Hemler,Enrico Mihich Book 1993 Springer Science+Business Media New York 1993 Activa

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G. Itelson – A Socratic Philosophertelet aggregation in response to all physiologic stimuli (Caen et al., 1966; reviewed by Nurden, 1989), was associated with the absence, or marked reduction of the content, of two platelet surface glycoproteins, GPIIb (135 kDa) and GPIIIa (95 kDa), (Nurden and Caen, 1974) provided the first evidence

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Olga Pombo,John Symons,Juan Manuel Torresers. Ligands bound by integrins include a variety of extracellular matrix molecules, cell surface Ig-like proteins, and some serum and complement proteins (Hemler, 1990; Hynes, 1992; Larson and Springer, 1990). Adhesion mediated by integrins is an essential feature of diverse processes such as tumor

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G. Itelson – A Socratic Philosopher In response to specific inflammatory signals, they can migrate out of the bloodstream, into the site of inflammation. At the inflammatory site, they express a different phenotype than in the bloos. Neutrophils and monocytes are easily stimulated to release reactive oxygen metabolites which act both

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Dmitri Fursaev,Dmitri Vassilevichot adhere spontaneously, but a variety of stimuli can induce β1- (VLA-4, VLA-5, VLA-6), β2- (LFA-1, CR3) and β3 integrin (IIb/IIIa) mediated cell-cell interactions. Exposure of lymphocytes, myeloid cells or platelets to phorbol ester (PMA) strongly includes cell aggregation (Rothlein and Springer, 1

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