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Titlebook: Case-Based Gynecological Oncology; Kavita Singh,Bindiya Gupta Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Behavioral and Structural Interfacese tumours are characterized by absence of p16 and presence of mutations in p53, KRAS, ARID 1A and PTEN. These tumours are aggressive, associated with higher recurrence rate and poor survival. Till now, the management strategies are same for both HPV dependent and independent tumours, although NHPV A
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Catherine H. Gebotys,Mohamed I. Elmasryncreasing rates of obesity. Other risk factors include diabetes, hypertension, polycystic ovarian syndrome (PCOS), nulliparity, and long term tamoxifen usage. Endometrial cancers have long been divided into oestrogen-dependent type I, and the less common, clinically aggressive, oestrogen-independent
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North Atlantic ocean crust and Icelandrole of lymphadenectomy in mucinous and neuroendocrine tumours is debatable. Adjuvant treatment needs to be tailored to the underlying histology and (for NECs) may benefit from a specialist MDT opinion.
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Development of Near-IR Angiographyistochemistry especially using CK7 and CK20 are the most commonly used antigens in differentiating between primary and metastatic ovarian tumours. Genetic testing is crucial for counselling and tailoring management. Treatment is mainly palliative chemotherapy while in select cases metastatectomy or cytoreductive surgery may be useful.
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David Mendlovic,Naim Konforti,Emanuel Marom mild nuclear atypia without destructive stromal invasion. These account for 10–15% of all epithelial tumours. The most common subtypes are serous and mucinous tumours. Surgery is the mainstay of management and these are associated with better prognosis than invasive carcinomas.
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Catherine H. Gebotys,Mohamed I. Elmasryspecially possibility of more conservative surgery in specific patient groups, preferred surgical approach and lymph node evaluation strategies. Adjuvant radiotherapy with or without chemotherapy may be given on the basis of intermediate and high risk factors on surgicopathological assessment.
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