Titlebook: Cardiovascular Disease, Volume 1; Genetics Qing K. Wang Book 2007 Humana Press 2007 Chromosom.bioinformatics.cardiovascular.gene therapy.ge

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Comparative Genomic Hybridization by Microarray for the Detection of Cytogenetic Imbalance,complex clinical phenotypes. Comparative genomic hybridization by microarray (array CGH) is a high-throughput and high-resolution method for the detection of microscopic and submicroscopic chromosome abnormalities, some of which may not be detectable by conventional cytogenetic techniques. In additi

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Construction of Somatic Cell Hybrid Lines,l antibodies and has made significant contributions to the field of human genetics through its applications in gene expression, gene mapping, and positional cloning of human disease genes. In our laboratory, we have employed this technique in the positional cloning of several genes for human disease

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LINKAGE Programs, A human disease gene can be identified by its chromosomal location (positional cloning). Linkage analysis is a key step in positional cloning. For monogenic disorders with a known inheritance pattern, model-based linkage analysis is effective in mapping the disease location. Therefore, model-based

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Linkage Analysis for Complex Diseases Using Variance Component Analysis,r disease, such as coronary artery disease and myocardial infarction, variance component analysis holds some unique advantages. This analysis approach is versatile, affording the user the ability to incorporate the interplay between risk factors, genetic susceptibility, the effect of environmental f

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Genome Resources and Comparative Analysis Tools for Cardiovascular Research,susceptibility. Genomic data and bioinformatics tools generated from genome projects, coupled with functional verification, offer novel approaches to study both rare single-gene and complex multigenic cardiovascular diseases. These approaches include gene mapping using genome variation, especially s

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Chromosome Substitution Strains, genetic basis for these traits and to characterize their functional consequences, mouse models are widely used, not only because of their genetic and physiological similarity to humans, but also because an extraordinary variety of genetic resources enable rigorous functional studies. Chromosome sub