Titlebook: Cardiovascular Biomarkers; Pathophysiology and David A. Morrow Book 2006 Humana Press 2006 cardiovascular.heart.heart disease.myocardial i

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Biomarkers of Myocardial Necrosisosis and myocardial infarction when elevated in the setting of acute cardiac ischemia. This chapter offers insight into evolution of cardiac biomarkers and offers thoughts regarding the future of necrosis biomarkers.

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Biomarkers of Necrosis in Heart Failure patients with heart failure. The inclusion of cardiac troponins in a multimarker strategy and the development of more sensitive immunoassays will likely further contribute to their acceptance as clinical tools in CHF.

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A Summary of Observed Data and Pre-Amble,ertheless, there are four important reasons to measure cardiac markers of necrosis in patients with STEMI: (1) confirmation of diagnosis, (2) monitoring of efficiency of reperfusion, (3) assessment of risk, and (4) infarct sizing.

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The Heavy-Water-Moderated Reactor,and troponin results, it is possible to stratify the patients into low-, intermediate-, and high-risk groups. In addition, troponin results are useful for selecting patients who benefit from treatment with lowmolecular-weight heparin, glycoprotein IIb/IIIa antagonists, and invasive management.

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Cardiac Troponin for Risk Assessment and Management of Non-ST-Elevation Acute Coronary Syndromeand troponin results, it is possible to stratify the patients into low-, intermediate-, and high-risk groups. In addition, troponin results are useful for selecting patients who benefit from treatment with lowmolecular-weight heparin, glycoprotein IIb/IIIa antagonists, and invasive management.

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C-Reactive Protein as a Tool for Risk Assessment in Primary Preventione, respectively. In clinical settings, hsCRP should be used in conjunction with lipid evaluation as part of global risk assessment. Improved knowledge of cardiovascular risk should lead to better compliance with lifestyle and pharmacological interventions designed to prevent future cardiovascular events.

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Biomarkers of Myocardial Necrosiste therapy that improves clinical outcome. Development and utilization of biomarkers has evolved substantially over the past three decades. The earliest biomarkers, such as alanine aminotransferase and lactate dehydrogenase, have fallen out of use with the development of moer sensitive and specific

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Analytical Issues for Clinical Use of Cardiac Troponins the biomarker of choice for the diagnosis of acute coronary syndromes (ACSs) and risk stratification of patients who present with ischemic symptoms suggestive of ACS. Despite these international guidelines, a number of analytic issues have slowed the acceptance and implementation of this test worl