Titlebook: Cardiac Mechanobiology in Physiology and Disease; Markus Hecker,Dirk J. Duncker Book 2023 The Editor(s) (if applicable) and The Author(s),

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Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenesis,his includes the acute feedback of cardiac mechanics to electrics (‘mechano-electric coupling’, MEC), which is achieved primarily through cellular and subcellular elements, including mechano-sensitive ion channels, biophysical signal transmitters and mechano-sensitive biochemical signalling pathways

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Computational Biomechanics of Ventricular Dyssynchrony and Resynchronization Therapy, due to an electrical substrate pathology causing delayed left ventricular activation. However, 40–50% of patients do not respond to treatment. In this book chapter, we review cardiac computer models of the electrophysiology, electromechanics, and hemodynamics of the heart that have been used to inv

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Therapeutic Innovations for Heart Failure,y high rates of hospitalization. Although there are specific, well-defined guidelines on pharmacological treatments, morbidity and mortality remain high. This chapter first summarizes fundamental basic mechanisms of cardiac hypertrophy due to increased afterload as well as heart failure as potential

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Mechanotransduction in Heart Development,art development. Here we discuss relatively well-studied examples of heart developmental processes that rely on transduction of the dynamic mechanical signals produced by heart function, heart looping and chamber expansion, the formation of the trabeculae, the formation of the valves, and the format

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Mechanobiology of Cardiac Fibroblasts in Cardiac Remodeling,nsiderations of their phenotype and mechanical behavior in vitro, which can diverge wildly from their in vivo behavior. With all this in mind, we also discuss some outstanding questions and challenges in CF research.

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Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration,rdiac injury. Therefore, the future cardiac regeneration strategies need to address the challenges of and questions on the role of biomechanics and mechanobiology in cardiac regeneration. This includes measurement and characterisation of multiscale mechanical properties of healthy and diseased cardi

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Cardiac Microvascular Endothelial Cells and Pressure Overload-Induced Cardiac Fibrosis,ast differentiation and thus excessive cardiac fibrosis and finally heart failure. Several factors have been shown to play a role in this endothelial cell dedifferentiation, such as transforming growth factor β1 and angiotensin II, and more are currently being assessed. This will pave the way for th