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Titlebook: Cardiac Glycosides; Günter Bodem,Hans J. Dengler Conference proceedings 1978 Springer-Verlag Berlin Heidelberg 1978 Bypass.Herzglykosid.as

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书目名称Cardiac Glycosides
编辑Günter Bodem,Hans J. Dengler
视频video
丛书名称International Boehringer Mannheim Symposia
图书封面Titlebook: Cardiac Glycosides;  Günter Bodem,Hans J. Dengler Conference proceedings 1978 Springer-Verlag Berlin Heidelberg 1978 Bypass.Herzglykosid.as
描述In spite of old vintage and 200 years of clinical use, digitalis remains an interesting therapeutic agent, to clinicians as well as to the pharmacologist, the biochemist, and colleagues in other diciplines of theoretic medicine. When a drug, however, has so many attractive facets, it seems proper and aJvis­ able for the success of a scientific meeting to focus on a number of well-defined aspects. This symposium was devoted to pharmacokinetics, drug metabolism, analytic procedures, blood level determinations, and their interpretation both for thera­ peutic and toxic situations. Considerable progress has been made during the last years in this area of digitalis research. The time was suitable for a critical reap­ praisal of facts and theories and for future planning. Our main intention was to relate analytic data and biochemical findings to clinical problems and questions. Despite the undoubtedly basic character of clinical pharmacology, it is neverthe­ less an applied science which should help to develop the rational basis of thera­ peutics. We are particularly grateful to the active participants who bore the burden of preparing presentations and - even worse - manuscripts. At the s
出版日期Conference proceedings 1978
关键词Bypass; Herzglykosid; assessment; circulation; heart; heart failure; medicine; pharmacodynamics; pharmacolog
版次1
doihttps://doi.org/10.1007/978-3-642-66904-0
isbn_softcover978-3-540-08692-5
isbn_ebook978-3-642-66904-0Series ISSN 0173-0282
issn_series 0173-0282
copyrightSpringer-Verlag Berlin Heidelberg 1978
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Evaluation of Different Methods for Determining Serum Concentrations of Cardiac Glycosides,al patients have included: the isolation of highly purified cardenolides, the recognition of the effects of digitalis on the electrocardiogram, a better definition of the effects of cardiac glycosides on myocardial contractility, conduction, and automaticity, and an appreciation of the role of elect
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Studies of the Metabolism of Digoxin and Digitoxin Using Double Isotope Dilution Derivative Methodsg the subsequent 9 days with a half-life of 1.4 days in one subject and 1.6 days in the other; 23%–56% of the calculated body pool of the drug was cumulatively excreted in the urine and stool, and digoxin was the only acid-hydrolyzable derivative of digoxigenin recovered..Biotransformation of orally
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Dihydrodigitoxin, a Metabolite of Digitoxin in Humans,rmacokinetics and metabolism with radioactively labeled cardiac glycosides were examined for the first time in the 1950s and 1960s. In the meantime, methods have become available which also make the determination of concentrations of nonlabeled digitalis glycosides in blood and urine possible. Rubid
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Tissue Distribution of Cardiac Glycosides,since the psychotic state outlasted the cardiac side-effects of digoxin intoxication. Four days af ter digoxin administration was stopped, a normalization of heart rate and sinus rhythm without extrasystoles in the ECG was observed. In contrast, the central side-effects such as anorexia, dizziness,
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Effect of Jejunoileal Bypass on the Bioavailability of Digoxin in Man,
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