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Titlebook: Cardiac Energetics; Basic Mechanisms and R. Jacob,Hj. Just,Ch. Holubarsch Conference proceedings 1987 Springer-Verlag Berlin Heidelberg 198

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Cardiac energetics: significance of mitochondriaxotonic contractile work, depending on the preload, afterload and beat rate in isolated superfused left guinea pig atria. The mitochondrial activity was measured by (1) continuous determination of the O. uptake rate, (2) the rate of .CO. production from labelled glucose or FFA and (3) separate measu
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Heat production and oxygen consumption following contraction of isolated rabbit papillary muscle at n electrode..Using a diffusion model we eliminated the effect of oxygen storage on the measured time course of oxygen uptake to determine the time constant of mitochondrial “off” kinetics. Two different approaches were followed. In Method 1, two steady-state levels were compared, whereas in Method 2
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Regulation of heart creatine kinasedard one-pulse NMR spectroscopy coupled with conventional biochemical analyses provides information about the average cytosolic concentrations of ATP, creatine phosphate (CrP), creatine (Cr) and H. in the heart. By combining these techniques, we tested the hypothesis that the velocity of the creatin
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ATPase activity of intact single muscle fibres of Xenopus laevis is related to the rate of force redvary considerably and differences are also found in their myosin composition. In this study a comparison was made between the rate of ATP hydrolysis estimated from the stable maintenance heat rate and the mechanical performance of fibres of type 1, 2 and 3..In the experiments, firstly the force-velo
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Developmental differences in myocardial ATP metabolismemia in neonatal and adult hearts. Hypothermia during ischaemia protected isolated adult and newborn hearts against ATP decline. Reperfusion after normothermic ischaemia resulted in higher ATP levels in newborn hearts with less release of ATP-catabolites. During normoxia adult hearts released mainly
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The effects of acute and chronic inotropic interventions on tension independent heat of rabbit papilExperiments were designed to test the working hypothesis that changes in peak twitch tension caused by pharmacological agents or changing haemodynamic conditions are accompanied by parallel changes in the tension independent heat (TIH) signal associated with Ca. cycling. We isolated the TIH signal b
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Chronic cardiac reactions. II. Mechanical and energetic consequences of myocardial transformation verations were realized on representative samples of normotensive rats and spontaneously hypertensive rats (SHR) in compensated stages, as well as in SHR in a state of congestive cardiac failure. Cardiac dynamic measurements were performed under Urethane anaesthesia and open chest conditions. Myosin i
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