Titlebook: Cardiac Drug Development Guide; Michael K. Pugsley Book 2003 Springer Science+Business Media New York 2003

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Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathologytems participating in the transduction of signal from the cell membrane to nuclear and other intracellular targets is the highly conserved mitogen-activated protein kinase (MAPK) superfamily. The members of MAPK family are involved in the regulation of a large variety of cellular processes, such as

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Development and Use of Platelet Glycoprotein Antagonists in Heart Diseasedisease (.). Although considerable effort has been expended to associate augmented platelet function with arterial thrombosis, it is more likely that the formation of platelet thrombi simply represents normal platelet function in the wrong location. It follows then that a rational approach to treati

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Nitric Oxide and Cardiac Ischemiaronary artery disease occurs, there is an abnormal diminished coronary blood supply relative to the myocardial oxygen demand known as hypoxia. The reduction in cardiac output is accompanied by increased systemic and pulmonary vascular resistance. These events are responsible for acute myocardial isc

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1557-2153 utting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and

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