Titlebook: Cardiac Bioelectric Therapy; Mechanisms and Pract Igor R. Efimov,Mark W. Kroll,Patrick J. Tchou Book 20091st edition Springer-Verlag US 200

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Virtual Electrode Theory of Pacingble cardioverters/defibrillators.. Engineers have been quite successful in designing these devices empirically, without a funda¬mental understanding of the underlying biophysical mechanisms. Over the past 15 years, two areas of research — optical mapping of electrical activity in the heart. and math

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Simultaneous Optical and Electrical Recordingsion on the heart. Much of the available knowledge is obtained from measurements of extracellular potentials or transmembrane potentials in the heart using electrical or optical methods. With an extracellular electrode in contact with the heart, activation of the cells is detected by observing the in

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The Bidomain Model of Cardiac Tissue: From Microscale to Macroscalert that is triggered by a highly coordinated spread of electrical activity. The currents underlying the propagation of impulses from cell to cell flow across the cell membrane and through both the intracellular and extracellular spaces in the heart. Over the past 30 years there has been considerable

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The Role of Electroporationical conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric field— induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some a

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Nonlinear Phenomena in Chemical Dynamicsspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.

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