Titlebook: Cancer of the Lung; From Molecular Biolo Alan B. Weitberg (Professor and Chairman) Book 2002 Springer Science+Business Media New York 2002

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Daniel F. Lorenz,Cordula Dittmer growth, early onset of metastases, prominent sensitivity to chemotherapy, and radiotherapy. Surgery and radiotherapy were the mainstays of therapy of SCLC until the end of the 1960s. Despite impressive responses with radiation, there were few long-term survivors in SCLC because of the propensity fo

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The Resilience of Punctuated Cooperationhasize that the traditional “standard” dose of 60–65 gy of radiation therapy for patients with unresected, locally advanced lung cancer yields local tumor control of only 15–17% when assessed by bronchoscopic biopsy 3 mo after completion of radiation therapy (.). Thus, new strategies will be importa

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Incidence and Etiologytterns of cigarette smoking, although other carcinogens have been implicated. Despite intensive investigation over the past several decades, the 5-yr lung-cancer survival rate remains a dismal 8–14%. This chapter reviews the recent trends in the epidemiology and etiology of lung cancer.

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Novel Uses of Radiation Therapy in the Treatment of Carcinoma of the Lunghasize that the traditional “standard” dose of 60–65 gy of radiation therapy for patients with unresected, locally advanced lung cancer yields local tumor control of only 15–17% when assessed by bronchoscopic biopsy 3 mo after completion of radiation therapy (.). Thus, new strategies will be important if this figure is going to be improved.

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Pathology of Lung CarcinomaThis chapter describes the histopathologic classification and the morphologic features of the major types and variants of lung carcinoma in order to provide a foundation for better understanding the pathogenetic significance of the molecular changes and the clinical issues associated with these lesions as described elsewhere in this text.

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Lung-Cancer StagingAccurate lung-cancer staging is essential for designing treatment programs and for determining a prognosis. Most importantly, a consistent, reproducible staging system is imperative for the execution of meaningful clinical trials of old and new therapeutic modalities, and for the extrapolation of the outcomes of trials to the general population.