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Titlebook: Cancer Imaging with Radiolabeled Antibodies; David M. Goldenberg Book 1990 Kluwer Academic Publishers 1990 Antigen.Staging.Tumor.carcinoma

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Clinical radioimmunodetection: The second decadet-term remissions were obtained in a few patients [12–14]. In 1965, Mahaley and Day reported on the localization of antibodies in gliomas in patients by means of autoradiography on excised specimens [15]. Finally, using radiolabeled antibodies to an undefined renal cancer antigen, Belitsky et al. [1
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Radiolabeling antibodies via the cyclic anhydride of DTPA — Experiences of 5 years used extensively in this and other laboratories for the preparation of DTPA-conjugated antibodies and other proteins. For example, in addition to both polyclonal and monoclonal antibodies, other proteins have been conjugated, such as fibrinogen [6,7], albumin [5], tissue plasminogen activator [8],
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In-vivo antibody imaging for the detection of human tumorsat radio-iodinated antibodies prepared against extracts of rodent tumors could localize in these tumors selectively [1,4,5]. Subsequently, it was found that this preferential tumor accretion of the radioactive antibodies was due mainly to anti-fibrin antibodies [1,6–8]; anti-fibrinogen antibodies we
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