Titlebook: Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances; F. M. Muggia Book 1989 Kluwer Academic Publishers 1989 ca

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https://doi.org/10.1007/978-3-662-08964-4 III trials are currently under way to further define the activity of trimetrexate in these diseases. This chapter summarizes the preclinical and clinical data from published and unpublished reports on this new agent.

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Alkylating agents: Mechanisms and modulation to review information that is considered common knowledge, but to discuss results that do not appear to agree with current dogma and also to introduce new ideas concerning the mechanism of action of alkylating agents with which the reader may not be familiar. In addition, the ability to modulate th

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Multidrug resistance: Clinical findings and implicationsclinical importance and the possible ways in which it may be circumvented. Multidrug resistance describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, and has been observed to occur frequently in mammalian cell lines and t