Titlebook: Cancer Chemo- and Immunopharmacology; 1. Chemopharmacology Georges Mathé,Franco M. Muggia Book 1980 Springer-Verlag Berlin Heidelberg 1980

宽容

Adjuvant Therapies of Postsurgical Minimal Residual Disease,t randomized clinical trials, either unicentric or policentric, are discussed..As fas as pediatric tumors are concerned post-surgical adjuvant chemotherapy was proved to play a useful role in prolonging the disease-free survival in Wilms tumor, rhabdomyosarcoma, Ewing sarcoma. Results obtained in th

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Limits of Animal Models in Cancer Chemotherapy, drugs, and interhost immune responses. In contrast, human tumors (e.g., ovarian carcinoma) show much greater variability. It is suggested that greater attention should be given to the study of the variables which distinguish the clinical setting from the animal models.

Ovulation

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Biochemical Control of High-Dose Methotrexate/Leucovorin Rescue Therapy, and malignant proliferating cells. Thus, under normal conditions, methotrexate (MTX) and Leucovorin (citrovorum factor, CF) in low doses can enter the cells by an active transport system, whereas in some malignancies — such as osteosarcoma — these substances only penetrate through the cell membrane

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collagenase

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解决

N-(Phosphonacetyl)-,-Aspartate (PALA): Current Status,olid tumors. The clinical dose-limiting factor is mucocutaneous toxicity which is reversible and dose-related. Delineation of the single-agent activity of PALA in human cancer must still await results of recently activated trials.

马具

,Synthesis, Biologic Effects, and Biochemical Properties of Some 2’-Azido- and 2’-Amino-2’-Deoxyarabf adenine inhibit the growth of some tumor cell lines in vitro and in vivo. 2’-Azidoarabinofuranosyl cytosine also interferes with the replication of herpes simplex virus types I and II. Whereas 2’-azidoara-C is resistant to deamination by a partially purified CdR deaminase from KB cells, the adenin

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