| 书目名称 | COX-2 Blockade in Cancer Prevention and Therapy |
| 编辑 | Randall E. Harris |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings whi |
| 出版日期 | Book 2003 |
| 关键词 | Prevention of breast cancer; cancer prevention; chemoprevention; prevention; prevention and control; tumo |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-59259-302-6 |
| isbn_softcover | 978-1-61737-304-6 |
| isbn_ebook | 978-1-59259-302-6Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer Science+Business Media New York 2003 |
发表于 2025-3-21 18:07:11
