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Titlebook: Breast Cancer Risk Reduction and Early Detection; Edward R.‘Sauter,Mary B.‘Daly Book 2010 Springer-Verlag US 2010 Breast.Cancer.Cancer che

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期刊全称Breast Cancer Risk Reduction and Early Detection
影响因子2023Edward R.‘Sauter,Mary B.‘Daly
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发行地址Includes supplementary material:
图书封面Titlebook: Breast Cancer Risk Reduction and Early Detection;  Edward R.‘Sauter,Mary B.‘Daly Book 2010 Springer-Verlag US 2010 Breast.Cancer.Cancer che
影响因子While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene?ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this b
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Breast Cancer Chemopreventionuction. All of these trials have capitalized on the known expression of estrogen receptors on many breast cancer cells, and the demonstrated efficacy of selective estrogen receptor modulators (SERMs) to treat breast cancer. Two SERMs, tamoxifen and raloxifene, have been studied extensively in random
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Surgical Management of Inherited Susceptibility to Breast Cancer risk-reducing salpingo-oophorectomy. Over the past decade, increasing data have become available regarding the efficacy of and the adverse effects from these surgical approaches. In this chapter we review the available literature, including the indications for such surgeries, as well as their risks
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Genetic and Molecular Approaches to Imaging Breast Cancerble. Although CT, MRI, and ultrasound have made great strides, none of the current modalities can image oncogene expression directly. No other reliable method is currently available to measure levels of specific receptors or mRNAs in vivo. In contrast to indirect approaches, noninvasive administrati
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Intraductal Approaches: Nipple Aspirate Fluid to Assist in Breast Cancer Detectionto breast examination and imaging studies (mammography supplemented with ultrasound, and magnetic resonance imaging [MRI] for certain indications). Abnormalities found by these techniques require an invasive needle or surgical biopsy to determine if cancer is present. Our approach is to determine no
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