Titlebook: Breast Cancer; Innovations in Resea Umberto Veronesi,Aron Goldhirsch,Maria Cristina Le Textbook 2017 Springer International Publishing AG 2

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Participating in service deliverye compiled by the International Agency for Research on Cancer (IARC) and obtained from the GLOBOCAN platform (Ferlay 2012). Detailed information about the source of data and the methods used for countries lacking incidence or mortality data are available in an article by Ferlay et al. [1].

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Making the Most of Fieldwork EducationBRCA1 gene and the identification of TP53 as the gene underlying Li–Fraumeni syndrome, both in 1990. In the modern era, next-generation sequencing technologies have been widely adopted, providing less expensive more comprehensive analysis of multiple genes concurrently in individuals at increased ri

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Turning business into e-business, node metastases, so that the extent of residual cancer can be measured and reported. Of course, the tumor bed can become very subtle after effective neoadjuvant chemotherapy, and improving treatments make this ever more likely. Posttreatment residual disease is often detected by light palpation of

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Dispelling the myths of e-business,mutations, and small insertion/deletions of certain genes can be associated with carcinogenesis and tumor progression. These so-called cancer drivers supposedly confer either growth advantages or protection from therapeutic stress.