Titlebook: Brain and Human Body Modeling; Computational Human Sergey Makarov,Marc Horner,Gregory Noetscher Book‘‘‘‘‘‘‘‘ 2019 The Editor(s) (if applic

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https://doi.org/10.1007/978-3-319-12163-5work by disrupting intracellular macromolecules that have high dipole moments whose functions are critical for tumor cells progressing through mitosis. However, the distribution of electric fields and the deposition of energies within the brain are poorly understood. Using finite element computer mo

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Ton J. Cleophas,Aeilko H. Zwindermantherapy including surgery, radiation, and chemotherapy, the prognosis remains poor with a median survival of around 2 years. Tumor-treating fields (TTFields) is a new frontier in cancer therapy and has been recently approved for the treatment of GBM. This chapter discusses emerging concepts of brain

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Ton J. Cleophas,Aeilko H. Zwinderman are used to calculate the intensity of TTFields as a measure of therapeutic “dose.” However, the antitumor efficacy also depends on the direction and exposure time of the induced fields. We recently proposed a new FE approach for TTFields dosimetry that incorporates all these parameters in order to

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Ton J. Cleophas,Aeilko H. Zwindermanmponents that are known to exhibit electric conduction properties and represent them as parts of a complex circuitry. In particular, we discuss conductivity of the membrane, ion channels, actin filaments, DNA, and microtubules, each of which play important roles in the biological functioning of the

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Ton J. Cleophas,Aeilko H. Zwindermanrequency (RF) coil performance and safety assessment typically includes numerical EM simulations with a set of human body models. The dimensions of mesh elements used for discretization of the EM simulation domain must be adequate for correct representation of the MRI coil elements, different types

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https://doi.org/10.1007/978-3-030-33970-8e imaging (MRI). Numerous scan parameters and a multiplicity of fields yield a complex MR environment for device safety assessment. Computational human models are used to quantify the RF-induced energy at the AIMD ports during the evaluation of RF-induced malfunction and unintended stimulation hazar

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