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Titlebook: Brain Tumor Invasiveness; Ronald H. Goldfarb Book 1994 Springer Science+Business Media Dordrecht 1994 Grading.angiogenesis.brain.brain tum

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发表于 2025-3-21 18:32:04 | 显示全部楼层 |阅读模式
期刊全称Brain Tumor Invasiveness
影响因子2023Ronald H. Goldfarb
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图书封面Titlebook: Brain Tumor Invasiveness;  Ronald H. Goldfarb Book 1994 Springer Science+Business Media Dordrecht 1994 Grading.angiogenesis.brain.brain tum
影响因子It is widely appreciated that the pathophysiology of advancedbrain cancer is intimately related to the extent of tumorinvasiveness. A prerequisite for comprehensively understandingneuro-oncology is therefore the elucidation of the biochemical andmolecular properties of tumor cells that contribute to theirinvasiveness. An understanding of tumor invasion for central nervoussystem tumors is crucial since malignant brain tumors are very highlyinvasive and extensively destroy adjacent neural brain tissue.Moreover, they are angiogenesis-dependent and lead to the death ofpatients by expanding within the limited space of the cranium. As morespecific insights are gained towards a full understanding of thecomplex process of tumor invasiveness of brain tumor cells, it shouldbe possible to design strategies for the early diagnosis and treatmentof invasive, advanced brain tumors. There is therefore an urgent needto better understand the cellular properties of brain tumor cellsresponsible for invasiveness. .This special issue of the.JOURNAL OF NEURO-ONCOLOGY. provides astate-of-the-art review of the general understanding of the process oftumor invasion. In addition, the articles emphasize specif
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Matrix degrading metalloproteinases,ed properties that allow them to be classified into a family of enzymes. They are secreted by various cell types as the cells effect their surrounding extracellular matrix. Such effects occur during normal physiologic tissue remodeling but also during pathologic processes such as tumor cell invasion
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The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and rtion is fundamental to events that require tissue remodelling, TIMPs regulate normal biological processes by inhibiting MMPs, and are of importance in pathological conditions. In this chapter we review evidence for the suppressive role of TIMP-1 in the malignant progression of cancer and of its regu
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Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an ,umor cell invasion are still unclear. In this study, we have quantitatively assayed a glioblastoma cell line for its ability to migrate through a polycarbonate filter coated with matrigel which contains a complex of multiple basement membrane components. At 48 h the glioblastoma cell line (U251) sho
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Migration of fresh human malignant astrocytoma cells into hydrated gel wafers ,,h grade human malignant astrocytomas into host rat brain. We now study the migratory capacity of fresh human malignant astrocytoma cells seeded on hydrated gel wafers composed of artificial basement membrane or collagen I, a normal and lesion-related CNS extracellular matrix component. Approximately
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Comparative aspects of neoplastic invasion of the brain, be considered a brain is present in the following taxonomic groups: Mollusca (Cephalopoda, Pulmonata) Sipunculida, Echiurida, Annelida, Arthropoda and Vertebrata (fishes, amphibians, reptiles, birds and mammals). The comparative approach (inter-, and intraspecies specific) provides a more informati
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