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Titlebook: Brain Acetylcholine and Neuropsychiatric Disease; Kenneth L. Davis,Philip A. Berger Book 1979 Plenum Press, New York 1979 brain.memory.ner

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Choline Administration to Patients with Huntington’s Disease or Tardive Dyskinesialustrate a new mode of medical therapy whereby choline, a naturally occurring dietary constituent and precursor of the neurotransmitter acetylcholine (ACh), is used to treat non-nutritional brain diseases in which cholinergic activity may be deficient.
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Psychological Effects of Cholinomimetic Agentsbalance, or inter-action, between adrenergic and cholinergic factors (Janowsky .., 1972a). Proposed most simply, mania was hypothesized to be a syndrome due to relatively diminished central acetylcholine (ACh) activity, compared to normal or increased noradrenergic and/or dopaminergic activity; and
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Lithium and Acetylcholine Interactionsa disease of cholinergic predominance and mania being the converse (Janowsky .., 1972a). As reviewed elsewhere (Janowsky .., 1972a), much psychopharmacologic information supports this possibility, including the observation that effective antidepressant treatments such as the tricyclic antidepressant
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Cerebrospinal Fluid Acetylcholinesterase in Psychosis and Movement Disorders1974). The majority of CSF AChE has been shown to derive from the brain with little if any contribution from the plasma (Yaksh .., 1975). The possibility of a large contribution to CSF AChE from the spinal cord is unlikely as histochemical studies of spinal tracts have failed to demonstrate apprecia
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Brain Cholinergic Enzymes in Schizophreniaergic system be investigated for possible abnormalities in mental disease including the schizophrenias. The enzymes of obvious interest are those which synthesize and hydrolyze ACh. In addition, the levels of the two substrates acetylcoenzyme A and choline are of great importance, as well as the tur
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Red Cell Choline and Affective Diseaset 50 years to the role of acetylcholine (ACh) in a variety of centrally mediated disease states. The identity and involvement of ACh in neurotransmitter function have been known to investigators for over five decades. Nevertheless, a concrete understanding of the contribution of ACh to various centr
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