Titlebook: Botulinum and Tetanus Neurotoxins; Neurotransmission an Bibhuti R. DasGupta Book 1993 Springer Science+Business Media New York 1993 Antigen

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PC12 Cells as a Model for Neuronal Secretion of these cells and the various types of experiments in which they are employed. We will then discuss in some detail their use as a model for neuronal secretion. There are several extensive and authoritative reviews on PC12 cells which provide much more detailed information on the origin, differenti

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Transmitter Release in ,: Applicability of Quantal Models and Evidence for Postsynaptic Controlot only from the accessibility of individual neurons, and consequent ease of study, but also from the network properties of these neuronal arrays. A well-recognized advantage is that many molluscan neurons are distinct individuals. As a consequence, using criteria such as shape, size, position, elec

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Exo-Endocytotic Recycling of Synaptic Vesicles in Developing Neuronss: synaptic vesicles (SVs) and large dense core vesicles (LDCVs). SVs are small vesicles highly homogeneous in size (about 50 nm) which are clustered under the presynaptic plasmalemmma and contain non-peptide neurotransmitters.Their exocytosis is responsible for the fast, point-to-point signalling t

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Endosome Processing: Structural, Functional and Kinetic Interrelationsc membrane, a translocation step through the membrane into the cytoplasm must follow at some stage along the endocytic pathway. An awareness of the steps which are involved in endosome processing can be helpful to assess the mechanism by which the toxin can reach its site of action in the cell.