Titlebook: Botulinum Neurotoxins; Andreas Rummel,Thomas Binz Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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书目名称Botulinum Neurotoxins影响因子(影响力)




书目名称Botulinum Neurotoxins影响因子(影响力)学科排名




书目名称Botulinum Neurotoxins网络公开度




书目名称Botulinum Neurotoxins网络公开度学科排名




书目名称Botulinum Neurotoxins被引频次




书目名称Botulinum Neurotoxins被引频次学科排名




书目名称Botulinum Neurotoxins年度引用




书目名称Botulinum Neurotoxins年度引用学科排名




书目名称Botulinum Neurotoxins读者反馈




书目名称Botulinum Neurotoxins读者反馈学科排名

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Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmissr peptide bond in one of the three SNARE proteins, which are the core of the membrane fusion apparatus for synaptic vesicles. SNARE cleavage causes the blockade of neurotransmitter release. This chapter details the molecular basis for the highly selective substrate recognition and cleavage mechanism of CNT.

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JOT

Complexity of Botulinum Neurotoxins: Challenges for Detection Technology,gical, and spectrometric assays or combinations thereof have been developed, supplemented by DNA-based assays for the detection of the organism. In this review, advantages and limitations of the current technologies will be discussed, highlighting some of the intricacies of real sample analysis.

悲观

Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics,vidual domains is becoming clearer as significant advancements are made to exploit the unique biology of the catalytic and translocation domains. These opportunities and the status of their development will be reviewed in this chapter.

Charitable

Botulinum Toxin: Application, Safety, and Limitations,ients are excluded from further treatment. A more recently approved second serotype (BoNT/B) could be effective in those secondary non-responders, however, due to less potency in humans higher doses have to be applied leading to an only transient successful treatment. Other serotypes as BoNT/A and B, e.g., BoNT/C should be approved as medicines.