Titlebook: Bone-Metabolic Functions and Modulators; Felix Bronner,Mary C. Farach-Carson,Helmtrud I. Ro Book 2012 Springer-Verlag London 2012 metaboli

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Fibres, Whiskers, and Platelets,from tumors. The past two decades have witnessed an explosion in the knowledge of the biological function of these peptides at the molecular level and their use as therapeutics or as targets in certain diseases. This chapter will review their functions in bone.

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Composite Mechanics: Short Fibres, of vitamin D. Upon reaching target tissues, 1,25(OH).D binds to its specific receptor, the vitamin D receptor (VDR). This step enhances or inhibits the transcription of vitamin D target genes that carry out the physiological actions of 1,25(OH).D: mineral homeostasis, skeletal homeostasis, and cellular differentiation.

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Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics, of vitamin D. Upon reaching target tissues, 1,25(OH).D binds to its specific receptor, the vitamin D receptor (VDR). This step enhances or inhibits the transcription of vitamin D target genes that carry out the physiological actions of 1,25(OH).D: mineral homeostasis, skeletal homeostasis, and cellular differentiation.

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Parathyroid Hormone and Parathyroid-Hormone-Related Protein: Normal Function, Diseases, and Emerginn calcium homeostasis and bone formation. PTH was discovered in the acid extracts of parathyroid glands because it restored the blood calcium level in the parathyroidectomized dog [24]. The existence of PTHrP and its close resemblance to PTH was first suggested by Fuller Albright in 1941 and later d

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Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics,l ion homeostasis. Vitamin D becomes bound to the vitamin D binding protein, DBP, in the circulation and is transported to the liver where the enzyme vitamin D 25-hydroxylase (CYP2R1) adds a hydroxyl group on carbon 25 to produce 25-hydroxyvitamin D [25(OH)D]. When the 25(OH)D metabolite enters the

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